Introduction
Glass Expansion's HE-SIS (High Efficiency Sample Introduction System) was initially developed as a cutting-edge solution for single-cell sample analysis. Our dedicated team of experts have recently enhanced its design to deliver exceptional performance in a diverse range of applications. Whether you're conducting single-cell studies, analyzing single particles, investigating nanoparticles, or working with low-volume samples, the redesigned HE-SIS ensures remarkable results with an impressive transport efficiency of up to 95%. Experience superior performance and unparalleled versatility with Glass Expansion's HE-SIS.
Breakdown of HE-SIS
1 | Make up Gas Inlet |
2 | MicroJet Adaptor |
3 | UV Shield |
4 | High Pressure Interface Kit |
5 | MicroMist™ HE Nebulizer |
6 | Lotis™ HE Spray Chamber |
7 | Nebulizer Gas Inlet |
8 | UniFit Drain |
9 | Mount Assembly |
Key HE-SIS Components
Conventional ICP-MS spray chambers have low transport efficiencies (typically < 5% TE) that filter out larger droplets ( > 5µm) from the nebulizer aerosol. The Glass Expansion HE-SIS features three critical components to overcome this significant sample transport deficiency.
This specially designed concentric glass nebulizer is based on our popular MicroMist design, capable of efficiently nebulizing limited sample volumes at low sample and argon gas flow rates.

Our MicroJet gas adapter (Patent approved) shapes the nebulizer aerosol plume to reduce sample deposition on the spray chamber walls and enhance transport efficiency.

The Lotis HE spray chamber directly couples to the ICP-MS torch, providing the highest transport efficiency and excellent washout between samples.

Superior Performance
In a comparison of the average sensitivity, Glass Expansion’s HE-SIS provided a factor of 2 to 3 increase compared to another commercially available single-cell or laminar flow sample introduction system (BrandX). The sensitivity ratio of the HE-SIS to BrandX was averaged for 16 masses, ranging low to high at a nebulizer sample flow rate ranging from 4 to 100 uL/min.
This increase in sensitivity is indicative of the high quality design of the Glass Expansion HE-SIS and MicroJet which greatly improves the transport efficiency compared to other commercially available systems.
Optimizing Operating Conditions
With every sample introduction system, the operating conditions should be optimized in order to achieve the best performance possible. In our HE-SIS Webinar we highlight the optimization of the HE-SIS nebulizer and MicroJet.
This webinar is a great introduction to the HE-SIS and can be used as a tutorial to achieve optimum transport efficiency and understand each operating parameter of the HE-SIS and its effect on overall performance.
Instrument Specific Installation
In addition to high performance, it is also important to provide a simple and reliable means of installation. Therefore, every HE-SIS is designed to suit a specific instrument model, which includes a mounting bracket support, ensuring proper alignment of the laminar flow spray chamber.
Part Number | Description |
KT-1155 | HE-SIS for Agilent® ICP-MS |
KT-1172 | HE-SIS for TOFWERK icpTOF |
KT-1172 | HE-SIS for Thermo Scientific™ Q/RQ/TQ ICP-MS |
KT-1172
|
HE-SIS for Thermo Scientific™ Neoma MC-ICP-MS |
KT-1184
|
HE-SIS for PerkinElmer® NexION 1000, 1100, 2000, 2200, 5000 |
KT-1204
|
HE-SIS for PerkinElmer® NexION 300/350 |
KT-1205
|
HE-SIS for NU ATTOM |
KT-1213
|
HE-SIS for Thermo Scientific™ X Series |
KT-1215
|
HE-SIS for Thermo Scientific™ Neptune/Element |
KT-1219
|
HE-SIS for Nu Vitesse |
Customer Comments